CURRENT ASPECTS OF THE PROBLEM OF PLACENTAL DYSFUNCTION AND MISCARRIAGE OF INFECTIOUS AND INFLAMMATORY GENESIS

Placental dysfunction and miscarriage of infectious and inflammatory origin remain urgent problems in
modern obstetrics, significantly contributing to perinatal morbidity and mortality. This article reviews the
etiopathogenetic mechanisms of placental insufficiency, emphasizing the role of viral and bacterial infections,
immune responses, and systemic inflammatory reactions. Special attention is given to ozone therapy as a
promising complementary approach in treating such conditions. The biological effects of ozone—antibacterial,
anti-inflammatory, antioxidant, and immunomodulatory—are discussed as potential tools to improve maternal
and fetal outcomes in high-risk pregnancies.